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KMID : 0388019950060030174
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Korean Journal Gynecologic Oncology and Colposcopy
1995 Volume.6 No. 3 p.174 ~ p.182
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Interferon-a2a, 13-cis-retinoic Acid and Radiotherapy for Locally Advanced Squamous Carcinoma of the Uterine Cervix: preliminary Study
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Abstract
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Locally advanced cancer of the uterine cervix is a major cause of death worldwide. Standard treatment with radiotherapy for locally advanced cancer of the uterine cervix has a response rate of less than 50%. Recently concurrent chemoradiotherpay
has
been introduced but with some controversy.
Interferon and retinoic acid are inducible proteins which possess many biologic activities such as antiproliferative, immunomodulatory and antineoplastic properties. Combination of interferon acid has produced high response rates especially for
patients
with squamous cell carcinoma. And they radiation cytotoxicity as radiosensitizer.
This study was undertaken to assess the clinical efficacy of combination regimen with interferon-α2a, 13-cis-retinoic acid and radiotherapy from Dec. 1988 to Dec. 1994 at Severance hospital Yonsei university. Twenty seven patients of locally
advanced
squamous cell carcinoma of the uterine cervix enrolled in this study are evaluated for response and toxicity.
@ES The results were as follows:
@EN 1. Preliminary results of interferon-α2a 13-cis-retinoic acid and radiotherapy are 46.7% of response rate(33.3% complete response)and those of concurrent chemoradiotherapy are 41.7% of response rate(46.7% complete response).
2. Major toxicity of interferon-α2a, 13-cis-retinoic acid and radiotherapy is fever(60.0%), and only case of grade 2 anemia and one case of grade 1 AST/ALT elevation was noted. There was no grade 3 or 4 toxicity.
Systemic interferon-α2a, 13-cis-retinoc acid and radiotherapy is highly active, well tolerated therapy for locally advanced cervical cancer.
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